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. 2018 Apr 16;9:312. doi: 10.3389/fphys.2018.00312

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Copyright © 2018 Khatun, Shimozawa, Kito, Kawaguchi, Fujimoto, Ri, Kajikuri, Niwa, Fujii and Ohya.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effects of treatments with antiandrogens for 48 h on paxilline-sensitive outward K⁺ currents in MDA-MB-453 cells. (A–C) Currents were elicited by a 500-ms depolarizing voltage step between −80 and +60 mV from a holding potential (−60 mV) with 10-mV increments in MDA-MD-453 cells treated with vehicle (A, upper panel), 1 μM BCT (B, upper panel), and 1 μM EZT (C, upper panel). The application of 1 μM PAX reduced outward currents (A–C, lower panel). (D) Current density-voltage relationship for PAX-sensitive peak current amplitude. (E) Summarized data on PAX-sensitive current density at +40 mV in vehicle- (n = 10), BCT- (n = 10), and EZT- (n = 11) treated MDA-MB-453 cells. Results are expressed as means ± SEM. ^**p <0.01 vs. the vehicle control.