Table 2.
Clinical descriptive data of derivation and validation cohorts
| Derivation cohort (n=75) | Validation cohort (n=90) | p-value | |
|---|---|---|---|
| Age (yr) | 60.0 (56-62) | 59.0 (54-65) | 0.38 |
| Male sex | 73 (97) | 76 (84) | 0.09 |
| BMI | 27.7 (23.8-31.1) | 29.1 (25.7-32.5) | 0.46 |
| Diabetes | 25 (25) | 32 (36) | 0.18 |
| Hypertension | 51 (68) | 53 (59) | 0.26 |
| HCV+ | 63 (84) | 55 (61) | < 0.001 |
| Child-Pugh class A/B/C | 47/24/4 | 50/31/9 | 0.49 |
| TNM stage I/II/III/IV | 36/25/13/1 | 23/30/23/14 | < 0.001 |
| Barcelona stage 0/A/B/C/D | 1/16/15/38/5 | 2/23/32/24/9 | 0.02 |
| ECOG status 0/1/2/3 | 35/35/4/1 | 58/26/4/2 | 0.09 |
| AFP | 38.5 (13.1-215.4) | 29.4 (7.9-235.3) | 0.46 |
| Total bilirubin | 1.2 (0.7-1.9) | 1.2 (0.7-2.0) | 0.93 |
| Albumin | 3.2 (2.8-3.8) | 3.6 (2.1-3.98) | 0.01 |
| MELD | 9 (8-11) | 10 (7-12) | 0.47 |
Values are presented as median (range) or number (%). For continuous variables, median and interquartile were shown, and p-values were from Mann-Whitney U test. For categorical variables, counts (and frequency if binary) were shown, and p-values were from Fisher exact test. BMI, body mass index; HCV, hepatitis C virus; ECOG, Eastern Cooperative Oncology Group; AFP, α-fetoprotein; MELD, Mayo End Stage Liver Disease score.