Figure 3.

Thrombograms (mean ± SEM) depicting the effect on thrombin generation of EV-containing pellets “spiked” into SPP with (n = 6) or without (n = 12) collected with CTI. PBS was added to the standard pool plasma that was not spiked with EVs (control). Thrombograms were generated with different trigger either MP, PRP, or PPPlow reagent or without addition of trigger reagents (depicted vertically). The effect of EVs on thrombin generation seems to mainly be driven by PPL. The use of CTI is depicted in the horizontally.