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. 2018 Mar 26;7(1):1454777. doi: 10.1080/20013078.2018.1454777

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© 2018 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group on behalf of The International Society for Extracellular Vesicles.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 4. — EV-associated PPL activity measured by PPL activity assay. (A) EVs reduce the PPL clotting time of SPP, mainly those in 20K pellets, thus increasing the PPL activity. The blue and dotted lines represents the reference PPL clotting time (mean ± SD, n = 12) of SPP without addition of EVs. (B) The 20K pellets showed tendency towards larger particles correlating with increased PPL activity, although this was not significant. (C) A significant correlation between PPL clotting time and thrombin generation using PRP reagent (containing no PL) was observed, but this disappeared when using PPPlow reagent (containing PL). *P < 0.001.