Fig. 3.
Regulation of eNOS in mouse lungs from WT, Bmpr2+/−, and Bmpr2ΔEx2/+ mice. (a) Western blots of lung lysates from normoxic mice demonstrating phosphorylated S1177 and T495 and total eNOS, and β-actin. Molecular weight markers indicated. (b) Quantification of band densities corrected for total eNOS protein, as indicated. (c) Western blots of lung lysates from WT, Bmpr2+/−, and Bmpr2ΔEx2/+ mice treated with SU5416 and 10% oxygen for three weeks. (d) Quantification of band densities corrected for total eNOS protein, as indicated. Results expressed as mean ± SEM based on western blot data shown normalized to WT normoxic controls. One-way ANOVA with Bonferroni correction for between-group comparisons: *P < 0.05; **P < 0.01; #P < 0.005, as indicated. (a, b) Modified from Fig. 4 in Frump et al. with permission from the publishers.27 (c, d) Unpublished data.