Table 2.
Recovery from severe acute exacerbations of chronic obstructive disease measured at admission, discharge and in stable state
| Admission
|
Discharge
|
Stable state
|
Change
|
|||||
|---|---|---|---|---|---|---|---|---|
| Subjects n | mean±SD | Subjects n | mean±SD | Subjects n | mean±SD | Subjects n | mean±SD | |
| Spirometry | ||||||||
| FEV1 (L) | 39 | 1.05±0.52 | 37 | 1.10±0.52 | 28 | 1.35±0.57 | 28 | 0.28±0.37* |
| FVC (L) | 36 | 2.61±0.85 | 36 | 2.98±0.85 | 28 | 3.29±0.88 | 26 | 0.58±0.68* |
| Static hyperinflation | ||||||||
| IC (L) | 36 | 2.06±0.65 | 34 | 2.13±0.67 | 28 | 2.40±0.70 | 27 | 0.28±0.41* |
| IC (% predicted) | 36 | 74±20 | 34 | 76±20 | 28 | 88±20 | 27 | 10±17* |
| IC relative to admission (%) | 36 | 100±0 | 31 | 104.4±17.8 | 27 | 115.6±23.1 | 27 | 15.6±23.1* |
| FRC (L) | 28 | 4.86±1.64 | 25 | 4.36±1.29 | 22 | −0.33±0.48* | ||
| RV (L) | 28 | 3.76±1.34 | 25 | 3.09±1.08 | 22 | −0.50±0.66* | ||
| TLC (L) | 28 | 6.82±1.72 | 25 | 6.72±1.47 | ||||
| Dynamic hyperinflation | ||||||||
| IC after metronome (L) | 25 | 1.3±0.59 | 25 | 1.48±0.50 | ||||
| IC change after metronome (L) | 25 | −0.74±0.31 | 25 | −0.82±0.43 | ||||
| Symptoms | ||||||||
| CCQ | 39 | 3.7±0.9 | 38 | 2.7±1.0 | 25 | 1.9±1.1 | 25 | −1.7±1.1* |
| Borg | 39 | 4.4±2.2 | 38 | 2.7±1.7 | 25 | 1.7±1.7 | 25 | −2.2±2.4* |
| mMRC | 39 | 3.4±1.0 | 38 | 3.2±0.9 | 25 | 2.4±1.3 | 25 | −1.1±1.2** |
| CAT | 25 | 26.2±7.0 | 25 | 20.8±6.0 | 25 | 16.5±9.0 | 25 | −8.1±8.1* |
Notes: Data are presented as mean ± standard deviation or number.
*
p<0.01 significant improvement from admission to stable state by paired t-test.
**
Significant improvement from admission to stable state by nonparametric Wilcoxon rank test.
Abbreviations: FEV1, forced expiratory flow in one second; FVC, forced vital capacity; IC, inspiratory capacity; FRC, functional residual capacity; RV, residual volume; TLC, total lung capacity; CCQ, Clinical COPD Questionnaire; Borg, borg dyspnea score; mMRC, Modified Medical Research Council; CAT, COPD Assessment Test.