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. 2018 Feb 26;293(16):5821–5833. doi: 10.1074/jbc.RA118.002180

Figure 1.

Figure 1.

Compartmentalization of folate-dependent one-carbon metabolism. Reactions are catalyzed by the following: 1, 2, and 3, MTHFD1; 1m, MTHFD1L; 2m and 3m, MTHFD2 or MTHFD2L; 4 and 4m, SHMT; 5, glycine cleavage system; 6, MTHFR; 7, methionine synthase; 8, thymidylate synthase; 9, ALDH1L2.