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. 2018 Feb 26;293(16):5821–5833. doi: 10.1074/jbc.RA118.002180

Table 1.

Pathway analysis by MetaboAnalyst

Metabolic pathways that were found to be significantly altered (based on FDR) in Mthfd1l−/− embryos from unsupplemented dams. The rightmost column shows how each pathway has responded to formate supplementation (supplemented Mthfd1l−/− versus supplemented Mthfd1l+/+).

Pathway Total compounds Hits Unsupplemented FDR Supplemented FDR
Methane metabolisma 9 3 2.76E-06 5.32E-06
Citrate cycle (TCA cycle)b 20 6 0.0028 0.52
Alanine, aspartate, and glutamate metabolismc 24 8 0.0054 0.027
Arginine and proline metabolismc 44 10 0.0057 0.13
Glyoxylate and dicarboxylate metabolism 18 4 0.0057 0.39
Valine, leucine and isoleucine biosynthesisc 11 4 0.0057 0.63
Pyruvate metabolismb 23 4 0.0063 0.057
Glycine, serine, and threonine metabolisma,c 31 7 0.012 5.32E-06
Histidine metabolismc 15 2 0.018 0.020
Phenylalanine metabolismc 11 2 0.026 0.023
Phenylalanine, tyrosine, and tryptophan biosynthesisc 4 2 0.026 0.023
β-Alanine metabolism 17 4 0.028 0.13

a Pathways involved in 1C metabolism.

b Pathways for energy metabolism.

c Pathways involved in amino acids.