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The proposed model for TMEPAI-induced c-Maf ubiquitination and degradation in partner with NEDD4. TMEPAI on the plasma membrane interacts with the WW domain on NEDD4 via its PY motifs, which leads to NEDD4 activation by phosphorylation or an unknown mechanism in association with the plasma membrane. Activated NEDD4 thus mediates c-Maf ubiquitination and subsequent degradation in the proteasomes.
