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. 2018 Mar 5;293(16):6172–6186. doi: 10.1074/jbc.M117.816793

Figure 1.

Figure 1.

Effect of IN 124–125 TT/AA polymorphism on biochemical activities of indicated INLAIs. A, setup of IN-LEDGF/p75 interaction and IN multimerization HTRF assays. B, HTRF signal of interactions with IN TT (WT NL4-3) or AA variant in the absence of inhibitor. C–H, dose-response curves of IN-LEDGF/p75 inhibition (C–E) or IN multimerization (F–H) with IN TT (in black) or IN AA variant (in orange) for the studied compounds. Results shown as average ± S.D. of at least three independent experiments performed in duplicate.