Figure 5.

Specificity of dl-MSA for class I FH. a, structures of l-malic acid and mercaptosuccinic acid. b, Lineweaver-Burk plot of initial velocity at varied malate and different fixed MSA concentrations. c, Lineweaver-Burk plot of the initial velocity at varied fumarate and different fixed MSA concentrations. d, inhibition of the growth of the ΔfumACB_pPfFHΔ40 strain of E. coli by MSA. e, rescue of MSA-mediated growth inhibition of ΔfumACB_pPfFHΔ40 upon addition of malate. f, inhibition of the in vitro growth of intra-erythrocytic asexual stages of P. falciparum by MSA.