Table 1. Orthosteric binding-site residues in the VFT for basic amino acid ligands for GPRC6A.

Docked Amino acids	Orthosteric binding-site residues
L-Arg	Val64, Gly147, Tyr148, Ser149, Glu170, Ser171, Thr172, Asp218, Tyr220, Gln280, Asp303, Asn304, Leu411
L-Lys	Gly147, Tyr148, Ser149, Glu170, Ser171, Thr172, Thr216, Asp218, Tyr220, Leu278, Arg279, Asp303, Asn304
L-Ornithine	Val64, Gly147, Tyr148, Ser149, Glu170, Ser171, Thr172, Ala173, Tyr220, Gln280, Asp303, Asn304, Leu411
Consensus site (residues interacting with at least one amino acid)	Val64, Gly147, Tyr148, Ser149, Glu170, Ser171, Thr172, Ala173, Thr216, Asp218, Tyr220, Leu278, Arg279, Gln280, Asp303, Asn304, Leu411