Table 1.
Echocardiographic measurements and RVSP calculated by direct cardiac puncture in WT and KO mice.
| Measurements | WT (n = 6) | KO (n = 5) | P value |
|---|---|---|---|
| Weight (kg) | 28.47 | 28.76 | 0.93 |
| Heart rate (bpm) | 470.49 | 503.39 | 0.54 |
| LVAW diastole (mm) | 0.82 | 0.69 | 0.07 |
| LVID diastole (mm) | 3.53 | 3.46 | 0.84 |
| LVPW diastole (mm) | 0.96 | 0.83 | 0.29 |
| LV EF (%) | 60.39 | 58.67 | 0.87 |
| LV FS (%) | 34.03 | 30.75 | 0.71 |
| RV FS (%) | 39.19 | 51.38 | 0.19 |
| RVOT VTI (mm) | 21.37 | 17.30 | 0.15 |
| RVID diastole (mm) | 1.26 | 1.99 | 0.007 |
| RVAW diastole (mm) | 0.503 | 0.500 | 0.97 |
| PA peak velocity (mm/s) | 628.73 | 952.61 | 0.0028 |
| PA VTI (mm) | 22.13 | 30.68 | 0.012 |
| PAT (ms) | 16.18 | 8.94 | 0.002 |
| PVR (mm2/s) | 8.91 | 17.61 | 0.03 |
| RVSP (mmHg) | 16.01 WT (n = 3) |
35.39 KO (n = 3) |
0.0009 |
Bpm = beats per minute; LVAW = left ventricle anterior wall; LVID = left ventricle internal diameter; LVPW = left ventricle posterior wall; LV EF = left ventricle ejection fraction; LV FS = left ventricle fractional shortening; RVOT VTI = right ventricular outflow tract velocity time index; RVID = right ventricle internal diameter; RVAW = right ventricle anterior wall; PA VTI = pulmonary artery velocity time index; PAT = pulmonary artery acceleration time; PVR = pulmonary vascular resistance.