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. Author manuscript; available in PMC: 2018 Apr 23.
Published in final edited form as: Nature. 2018 Mar 21;555(7698):611–616. doi: 10.1038/nature25983

Extended Data Figure 7. Transcription factor binding disruption and transmission disequilibrium test.

Extended Data Figure 7

a–d, Comparison of predicted change in transcription factor binding for observed DNMs compared to null mutation model. Empirical P values derived from comparison with mutations simulated from the null mutation model. e, None of the non-coding element classes tested show any evidence of overtransmission from parents to affected children. Dots and bars represent the point estimate and 95% confidence intervals of estimates of transmission proportions, respectively.