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. Author manuscript; available in PMC: 2018 Apr 23.
Published in final edited form as: Gut. 2016 May 10;66(8):1358–1368. doi: 10.1136/gutjnl-2016-311818

Figure 2.

Figure 2

THZ1 suppressed the growth of KYSE510 xenografts and inhibited lung metastasis in NOD-SCID gamma (NSG) murine model. (A) Photographs of tumours from both vehicle and THZ1 (twice daily, 10 mg/kg, 24 days) treatment groups. (B) Tumour growth curves of mice treated with either vehicle or THZ1. Data represent mean±SD (****p<0.0001). (C) Weights of tumours from each mice at the endpoint (****p<0.0001). (D) H&E and immunohistochemical (IHC) staining of Ki67, CC3 and Cleaved Caspase-9 (CC9) in tumour tissue sections. Original magnification, ×400. (E) Representative images of lungs after Bouin’s fixation (left) and H&E staining of tissue sections (right). Original magnification, ×100. Representative tumour lesions are indicated by arrows. (F) Visible lung metastases were counted and graphed (*p<0.05).