TABLE 5.

Ability of the multiple-breath washout test to detect the presence of neutrophil elastase, respiratory infections and structural lung disease in pre-school children with cystic fibrosis who achieved three or more and two or more acceptable trials

	Lung clearance index		First moment ratio		Second moment ratio
	Three or more acceptable trials	Two or more acceptable trials	Three or more acceptable trials	Two or more acceptable trials	Three or more acceptable trials	Two or more acceptable trials
Neutrophil elastase
Sensitivity %	83 (59–96)	83 (59–96)	89 (65–99)	89 (65–99)	89 (65–99)	89 (65–99)
Specificity %	61 (43–76)	64 (46–79)	61 (43–76)	64 (46–79)	47 (31–64)	47 (30–65)
Respiratory infection
Sensitivity %	67 (43–85)	70 (47–87)	67 (43–85)	74 (54–87)	71 (48–89)	83 (63–93)
Specificity %	58 (39–75)	56 (38–72)	58 (39–75)	53 (37–68)	42 (25–61)	42 (27–58)
Bronchiectasis
Sensitivity %	66 (46–82)	70 (51–85)	65 (46–82)	69 (50–84)	83 (64–94)	84 (67–95)
Specificity %	59 (33–82)	69 (41–89)	59 (33–82)	63 (35–85)	53 (28–77)	63 (35–85)

Data are presented as median (range).