Figure 1.

Intergenerational Inheritance of Enhanced LTP through EE

(A) LTP is enhanced in 10-week EE compared to HC controls. ^∗∗∗p < 0.001 for main effect treatment repeated-measures ANOVA (F(1,12) = 11.86); n = 8 (10w EE); 6 (10w HC).

(B) Mating scheme: mice are subjected to EE for 10 weeks and mated, and the offspring are tested 3–4 months after birth. Controls spend the same amount of time in the HC.

(C) LTP is enhanced in mice born to EE fathers EE:HC (n = 10) compared to HC:HC (n = 10) controls. ^∗∗∗p < 0.001 for main effect treatment HC:HC versus EE:HC, repeated-measures ANOVA (F(1,18) = 18.74).

(D) LTP is not enhanced in the F2 generation. Error bars indicate SEM.