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. 2018 Apr 10;23(2):546–554. doi: 10.1016/j.celrep.2018.03.059

Figure 2.

Figure 2

Small RNA-Seq from Sperm Reveals Candidate miRs Potentially Linked to Intergenerational Transmission of Enhanced LTP after EE

(A) Pie chart illustrating the distribution of small RNA species in sperm obtained from naive WT mice.

(B) Venn diagram showing that, out of 1,886 miRs analyzed, 219 were expressed in sperm. This list of miRs was then searched for miRs implicated in brain function and development, synaptic plasticity, and learning and memory (PubMed search criteria “brain + learning + microRNA-X (let-X)”; more than 1 hit). This approach revealed 6 candidate miRs.

(C) Graph showing the 6 candidate miRNAs and the corresponding number of hits based on the PubMed search. PubMed IDs for the papers linked to miR212/132 are 22845676, 22246100, 19557767, 23520022, 27392631, 20613834; let-7d are 23425148, 21307844, 20557304, 25799420; let-7c are 25962166, 21676127; let-7-b are 21676127, 27539004; miR34c are 26402112, 21946562; miR124 are 24784359, 22837048.