. Author manuscript; available in PMC: 2019 May 1.

Published in final edited form as: Head Neck. 2018 Feb 10;40(5):943–954. doi: 10.1002/hed.25057

TABLE 1.

Summary of DNA Repair Pathway Gene Polymorphisms Investigated in Low-Risk, Non-Traditional HNSCC Patients

Gene Investigated	Study Design	Case/Control Size	Strength of HNSCC Association OR (95 % CI)	Subgroup Stratification
XRCC1 R194W (Homozygous)	Meta-analysis of 30 Studies (Flores-Obando et al¹⁶)	7,291/12,052	1.78 (1.13–2.82)	Asians
	Meta-analysis of 29 Studies (Lou et al¹⁷)	6,719/9,627	0.91 (0.77–1.08)	N/A (Total Population)
	Meta-analysis of 29 Studies (Lou et al¹⁷)	6,719/9,627	2.53 (1.16–5.53)	Smokers
XRCC1 R399Q (Homozygous & Heterozygous)	Meta-analysis of 30 Studies (Flores-Obando et al¹⁶)	7,291/12,052	1.14 (1.01–1.27)	Caucasians
	Meta-analysis of 29 Studies (Lou et al¹⁷)	6,719/9,627	0.99 (0.90–1.09)	N/A (Total Population)
	Meta-analysis of 29 Studies (Lou et al¹⁷)	6,719/9,627	0.7 (0.43–1.15)	Smokers
XPD D312N (Heterozygous)	Meta-analysis of 30 Studies (Flores-Obando et al¹⁶)	7,291/12,052	1.14 (1.01–1.29)	N/A (Total Population)
XPD D312N (Heterozygous)	Meta-analysis of 9 Studies (Hu et al¹⁸)	2,670/4,452	1.11 (0.99–1.24)	N/A (Total Population)
*HEL308* (Homozygous & Heterozygous)	GWAS of European Studies in INHANCE Consortium (McKay et al¹⁹)	8,605/16,226	1.13 (1.08–1.17)	N/A (Total Population)
			1.19 (1.08–1.31)	Age < 50 Years
			1.03 (0.93–1.14)	Never smokers
			1.04 (0.93–1.18)	Never drinkers
*HEL308* (Homozygous)	Case-Control Study of Patients in the Boston, MA Area (Liang et al²¹)	575/676	0.78 (0.57–1.06)	N/A (Total Population)
*HEL308* (Homozygous)	Case-Control Study of Chinese Nationals (Yuan et al²²)	397/900	0.98 (0.82–1.18)	N/A (Total Population)