TABLE 2.
Alteration Frequency of FA Pathway and FA Pathway-Associated Genes Within the 528-Patient TCGA HNSCC Provisional Dataset Retrieved Using cBioPortal.65,66 (Color-coding of genes in the table corresponds to color-coding of gene products in Figure 1 depicting the FA-pathway)
| Gene (Alias) | Number of Cases Altered (504 Total) | Percent of Cases Altered |
|---|---|---|
|
| ||
| FA Pathway | ||
| FANCA | 11 | 2.20% |
| FANCB | 18 | 4% |
| FANCC | 13 | 2.60% |
| FANCD1 (BRCA2) | 27 | 5% |
| FANCD2 | 13 | 2.60% |
| FANCE | 3 | 0.60% |
| FANCF | 5 | 1% |
| FANCG | 26 | 5% |
| FANCI | 9 | 1.80% |
| FANCJ (BRIP1) | 15 | 3% |
| FANCL | 6 | 1.20% |
| FANCM | 14 | 2.80% |
| FANCN (PALB2) | 8 | 1.60% |
| FANCO (RAD51C) | 3 | 0.60% |
| FANCP (SLX4) | 10 | 2% |
| FANCQ (ERCC4) | 5 | 1% |
| FANCS (BRCA1) | 13 | 2.60% |
|
| ||
| FA Pathway-Associated | ||
| BRCA2 | 27 | 5% |
| BRCA1 | 13 | 2.60% |
| RB | 28 | 6% |
| ATR | 76 | 15% |