Table 2.
Cytotoxicity data of compounds isolated from the roots of S. deserta.
Compound | Cytotoxic activitya, IC50 (μM)
|
||||
---|---|---|---|---|---|
A549 | MDA-MB-231 | KB | KB-VIN | MCF-7 | |
1 2β, 3β, 24β - trihydroxy - 12, 13 - cyclo - taraxer-l4-en-28oic acid | >40 | >40 | >40 | >40 | >40 |
3 6, 7-dehydroroyleanone | 6.568±0.176 | 13.320±1.473 | 8.916±1.186 | 8.020±0.258 | 20.779±1.257 |
4 horminone | 19.354±0.342 | 23.624±1.812 | 29.581±1.117 | 24.455±0.459 | 34.833±0.922 |
5 7-O-methylhorminone | 7.194±0.260 | 8.450±0.174 | 10.281±0.648 | 7.303±0.285 | 13.716±0.654 |
6 sugiol | >40 | >40 | >40 | >40 | >40 |
7 demethylcryptojaponol | 23.187±0.996 | 26.243±0.140 | 23.501±0.960 | 21.804±0.525 | 28.590±0.336 |
8 14-deoxycoleon U | 12.249±0.719 | 18.062±0.008 | 7.689±0.416 | 7.707±0.187 | 8.695±0.975 |
Paclitaxel (nM)b | 4.191±0.493 | 5.497±0.240 | 3.529±0.398 | 2345.602±35.469 | 11.941±1.305 |
IC50 values based on triplicate five points, presented as the mean ± S.D.
Experimental control.