Table 2. Examples of Salmonella genes that delay host DNA degradation after P22 infection.
Genes are ranked according to descending order of selection strength of mutants (see Experimental Procedures). See Supplementary Table S2 for more candidate genes in this class.
| Gene name | STM14 open reading frame locus_tag | Pathway | Function |
|---|---|---|---|
| wzxE | 4724 | ECA | common antigen translocase (flippase) |
| yfhK | 3143 | nd | putative 2-component sensor protein |
| glmU | 4657 | ECA | bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase |
| mdoG | 1317 | periplasmic glucan synthesis | glucans biosynthesis |
| wecG | 4727 | ECA | Probable UDP-N-acetyl-D-mannosaminuronic acid transferase |
| ygfY | 3679 | nd | unknown function |
| wecD | 4722 | ECA | TDP-fucosamine acetyltransferase |
| fliF | 2390 | flagellar biosynthesis | flagellar M-ring protein |
| wecE | 4723 | ECA | TDP-4-oxo-6-deoxy-D-glucose transaminase |
| – | 4350 | nd | unknown function |
| yebA | 2299 | nd | cell wall endopeptidase, family M23/M37 |
| fliJ | 2394 | flagellar biosynthesis | flagellar biosynthesis chaperone; rod/hook and filament chaperone |
| – | 5018 | nd | unknown function |
| oxyR | 4959 | nd | transcriptional regulator |
| wecB | 4718 | ECA | UDP-N-acetylglucosamine 2-epimerase |
| ybeB | 0750 | nd | unknown function |
| ycfM | 1381 | nd | putative outer membrane lipoprotein |
| – | 2444 | nd | unknown function |
| wecC | 4719 | ECA | UDP-N-acetyl-D-mannosamine dehydrogenase |
| ompA | 1214 | nd | outer membrane protein A precursor; osmoregulation |
| flgC | 1346 | flagellar biosynthesis | flagellar basal body rod protein; part of proximal portion of the flagellar basal body rod |
| fliO | 2399 | flagellar biosynthesis | flagellar biosynthesis; a membrane components of the flagellar export apparatus |
| sdhD | 0852 | nd | succinate dehydrogenase hydrophobic membrane anchor protein |
*
nd = not determined