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. Author manuscript; available in PMC: 2019 Apr 1.
Published in final edited form as: Ann Neurol. 2018 Mar 30;83(4):756–770. doi: 10.1002/ana.25198

Figure 3.

Figure 3

(A). Compound muscle action potential (CMAP) was recorded from a p21 Fig4+/+ mouse paw. The motor nerve conduction velocity (CV) was 22m/s. (B). The same experiment was done in a p21 Fig4−/− mouse and showed a 50% reduction of CV. (C–D). Mouse sciatic nerves were teased into individual fibers in liquid Epon and imaged. Internodal length and diameter were measured and plotted. The slope in Fig4−/− mice was lower than that in Fig4+/+ mice, supporting shortened internodal length in Fig4−/− mice. (E). The frequency vs. diameter plot allows a better visualization of shortened internodes mainly involving those longest (largest) fibers. (F). INL = internodal length; N = number of mice; p<0.05 for the comparison of both internodal length and slope.