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. 2018 Apr 23;8:6411. doi: 10.1038/s41598-018-24398-9

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Top: F-test 1 of unique metabolic syndrome or allostatic load index association with grey matter after removing the effects of Framingham stroke risk and socio-demographic variables. Significant results extend the right insular and opercular cortex. Bottom: Post-hoc t-test shows an association between allostatic load index and lower voxelwise grey matter after removing the effects of metabolic syndrome, Framingham stroke risk and socio-demographic variables. Significant voxels were located along the right insular and opercular cortex, superior temporal gyrus and temporal pole. Blue represents regions significant at p < 0.05, threshold-free cluster enhancement, multiple comparisons corrected. P, posterior; A, anterior; R, right; L, left; Coordinates are in MNI space.