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. 2018 Apr 23;8:6411. doi: 10.1038/s41598-018-24398-9

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Top: F-test 3 of unique Framingham stroke risk or metabolic syndrome association with fractional anisotropy (FA) after removing the effects of allostatic load index and socio-demographic variables. Significant voxels are located in the body of corpus callosum. Bottom: F-test 2 (top) of unique Framingham stroke risk or allostatic load index and F-test 3 (bottom) of unique Framingham stroke risk or metabolic syndrome association with widespread mean diffusivity (MD) values. Results primarily extend the anterior thalamic radiation, corona radiata, corpus callosum, and internal and external capsule. Results represent voxels significant at p < 0.05, threshold-free cluster enhancement, multiple comparisons corrected. Significant regions are dilated for illustrative purposes, overlaid on a green skeleton and corrected for multiple comparisons. A, anterior; R, right; L, left. Coordinates are in MNI space.