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. 2018 Apr 23;8:6411. doi: 10.1038/s41598-018-24398-9

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Post-hoc t-tests of Framingham stroke risk and lower white matter integrity. Post-hoc t-tests show an associations of higher Framingham stroke risk with lower fractional anisotropy (FA; top) and higher mean diffusivity (MD; bottom) after removing the effects of metabolic syndrome, allostatic load index and socio-demographic variables. Significant fractional anisotropy voxels extend bilaterally in the corona radiata, corpus callosum, forceps major, superior longitudinal fasciculus, in the right hemisphere along the anterior thalamic radiation, corticospinal tract and internal capsule, as well as in the left inferior fronto-occipital fasciculus and posterior thalamic radiation. Significant mean diffusivity voxels are present in similar regions but more widespread and less lateralised than with fractional anisotropy. Results represent voxels significant at p < 0.05, threshold-free cluster enhancement, multiple comparisons corrected. Significant regions are dilated for illustrative purposes, overlaid on a green skeleton. R, right; L, left. Coordinates are in MNI space.