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. 2018 Apr 23;9:1603. doi: 10.1038/s41467-018-03886-6

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© The Author(s) 2018, corrected publication 2023

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Fig. 8 — Proposed model for IRAK-M activation mechanism by IRAK1 and PIN1, upon IL-33 stimulation. a IRAK-M is located in the Myddosome in association with IRAK1. PIN1 is phosphorylated at Ser71 and is inactive. b Upon IL-33 stimulation, IRAK1 is hyper phosphorylated and active and phosphorylates IRAK-M at S110P site. PIN1 is dephosphorylated and active. c PIN1 binds to IRAK-M phosphorylation site and induces conformational change that promotes its dissociation from the Myddosome. d Released IRAK-M translocates into the nucleus and induces the expression of its target genes for downstream T_H2 cell differentiation and inflammation