Table 2.

Conservation of HECT-interacting proteins.

S. cerevisiae HECTs	S. cerevisiae interacting proteins	Homo sapiens HECTs	H. sapiens interacting proteins	Function of HECT-interacting proteins in yeast	References
RSP5	UBC1	NEDD4L, ITCH, SMURF1, WWP2	UBE2K	Ubiquitin-conjugating enzyme	69
RSP5	UBC4, UBC5	NEDD4, NEDD4L, HECW1, HECW2, ITCH, SMURF1, SMURF2, WWP1, WWP2	UBE2D1, UBE2D2, UBE2D3, UBE2E1, UBE2E3	Ubiquitin-conjugating enzymes	69
RSP5	UBC6	NEDD4L, HECW1, ITCH, WWP2	UBE2J2	Ubiquitin-conjugating enzyme	69
RSP5	UBI4	HECW1	UBC	Polyubiquitin	70
RSP5	RPN10	NEDD4, NEDD4L, HUWE1, SMURF1	PSMD4	26S proteasome regulatory subunit	71
RSP5	RPO21	NEDD4, WWP1, WWP2, ITCH, SMURF1	POLR2A	DNA-directed RNA polymerase II subunit	72
RSP5	RPB2	NEDD4, HECW2, ITCH, WWP1	POLR2B/RPB2	DNA-directed RNA polymerase II subunit	72
RSP5	RPB3	NEDD4, ITCH, WWP1, WWP2	POLR2C	DNA-directed RNA polymerase II subunit	72
RSP5	RPB5	NEDD4, ITCH, WWP2	POLR2E	DNA-directed RNA polymerases I, II, and III subunit	72
RSP5	RPB7	WWP1	POLR2G	DNA-directed RNA polymerase II subunit	72
RSP5	SEC7	ITCH	ARFGEF2	Vesicular transport protein, guanine exchange factor	73
RSP5	HSE1	ITCH	STAM1, STAM2	Vacuolar protein-sorting machinery	74
RSP5	HSP82	WWP1	HSP90AA1	ATP-dependent molecular chaperone	75
RSP5	LHP1	SMURF1	SSB	tRNA maturation control	76
RSP5	NFI1, SIZ1	SMURF2	PIAS3	Sumo conjugation	77
TOM1	MLC1	HUWE1	MYL6B	Myosin light chain	78
TOM1	HSP82, HSC82	HUWE1	HSP90AA1, HSP90AB1, HSP90B1	ATP-dependent molecular chaperones	75
UFD4	UBC4	TRIP12	UBE2D1, UBE2D4	Ubiquitin-conjugating enzyme	69