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Location of HCM-linked actin mutations on the actin structure. Left, high-resolution structure of Tm bound to three subunits of one strand of F-actin in the open and closed states. Right, Location of Tm-class (T-class, labeled in green), myosin-class (M-class, labeled in red), and myosin and Tm-class (MT-class, labeled in blue) amino acid changes. Both images were produced using PDB 5N0J (Risi et al., 2017).
