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Pharmacodynamic analysis of danofloxacin in infected rabbits targeting the blood, liver, spleen, and lung.
| Parameter (units) | Blood | Liver | Spleen | Lung |
|---|---|---|---|---|
| Emax (Log10 cfu/mL) | 3.98 | 3.1 | 4.41 | 4.74 |
| E0 (Log10 cfu/mL) | 0.00 | 0.00 | 0.00 | 0.01 |
| EC50 | 66.54 | 89.84 | 145.66 | 148.18 |
| AUC24 h/MIC for a 3 Log10 cfu/mL reduction | 121.30 | 354.28 | 216.64 | 228.66 |
| Slope (N) | 1.86 | 2.47 | 1.90 | 1.26 |
AUC24h/MIC: area under the concentration-time curve from 0 to 24 h/minimum inhibitory concentration ratio.
