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. 2018 Apr 23;8:6375. doi: 10.1038/s41598-018-24714-3

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Cell therapy using hiPSC-derived CD9⁻CD140a⁺CD140b⁺CD271⁺ cells for acute kidney injury (AKI) model mice. (A) Time course analysis of blood urea nitrogen (BUN, left) and serum creatinine (Cre, right) levels in ischemia/reperfusion (I/R) AKI mice that received a renal subcapsular transplantation of hiPSC-derived CD9⁻CD140a⁺CD140b⁺CD271⁺ cells (n = 4, iPSC-RPs, diamond) or saline injection (n = 4, square). Statistical significance: ***P < 0.001 vs. saline, **P < 0.01 vs. saline and *P < 0.05 vs. saline after multiple testing adjustment. Least square means and 95% confidence intervals were estimated according to the mixed effects model for repeated measures. (B) Representative section images of the host mouse kidney samples that received saline injection (upper panels) or transplantation of iPSC-RPs (lower panels) on day 12 after I/R and transplantation. Tubular necrosis, urinary cast, tubular dilatation and loss of tubular borders can be seen in each treatment group. The arrows indicate representative areas of each finding. Scale bars, 100 µm. (C) Histological intensity scores of tubular necrosis, urinary cast, tubular dilatation and loss of tubular borders in host kidneys on day 12 after I/R injury (n = 4). Statistical significance: *P < 0.05 vs. saline after multiple testing adjustment. BUN, blood urea nitrogen; Cre, creatinine; HE, Hematoxylin and eosin; PAS, periodic acid-Schiff; NS, not significant.