Fig. 2. Differential allele expression (DAE) at AVPR1a in postmortem hippocampal samples.

a Schematic of hypothesized cis-effect of one STR on gene expression (increase in expression represented by white arrow). This effect can be captured in subjects heterozygous for a reporter SNP. STRs were considered together in order to capture an additive effect. Two-locus categorization (defined by RS1 and AVR risk alleles) is associated with (b) DAE (p = 0.017) and (c) externalizing behaviors in a dose-dependent manner (p = 0.009). Three-locus categorization (defined by RS1, AVR, and RS3 risk alleles) is associated with (d) DAE (p = 0.018), but does not improve the effect on (e) externalizing behaviors (p = 0.025). Each dot represents one subject