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Chemical stability of lactams, named as described in Fig. 2, in 30% MeOH or 1:1 acetonitrile (ACN): water at 21 °C and pH 6.7.
| Compound | Half-life (t1/2, h)* | |
|---|---|---|
| 30% MeOH | ACN:Water, 1:1 | |
| (+)-GR24 | 80 | 3375 |
| rac-1 | 110 | 720 |
| rac-2 | 21 | 140 |
| rac-3 | 3 | 3.8 |
| rac-4 | 3.3 | 4.4 |
| rac-5 | 2 | 24 |
| rac-6 | 190 | 528 |
| rac-7 | 11 | 17 |
| rac-8 | 230 | 1080 |
| rac-9 | 1100 | 2900 |
* t1/2 values were extrapolated from the plots of peak area versus time.
