Table 1.
Associations of trajectory of body fatness with genetic risk score (GRS) in women and men
| Lean-medium | Medium-medium | Lean-heavy | Medium-heavy | P for trend | |
|---|---|---|---|---|---|
| Women | |||||
| Mean GRS (SD) | 87.0 (6.3) | 88.3 (6.2) | 88.4 (6.0) | 89.9 (6.2) | <0.001 |
| OR (95% CI) per 10-allele increment in GRSa | 1 (reference) | 1.40 (1.27–1.54) | 1.43 (1.30–1.58) | 2.15 (1.91–2.43) | <0.001 |
| Men | |||||
| Mean GRS (SD) | 87.1 (6.4) | 88.0 (6.3) | 88.0 (6.3) | 89.4 (5.9) | <0.001 |
| OR (95% CI) per 10-allele increment in GRSa | 1 (reference) | 1.26 (1.12–1.42) | 1.27 (1.13–1.43) | 1.81 (1.53–2.15) | <0.001 |
SD, standard deviation.
aMultinomial logistic regression was used to derive ORs and 95% CIs. Ordinal logistic regression was used to calculate the P-value for trend test.