Table 3.
Adverse events (N)
| Adverse events | Grade 1 | Grade 2 | Grade 3 | Grade 4 |
|---|---|---|---|---|
| Anemia | 20 | 1 | 0 | 0 |
| Leukocytosis | 1 | 1 | 1 | 0 |
| Platelet count decreased | 1 | 0 | 1 | 0 |
| Hyponatremia | 3 | 0 | 0 | 0 |
| Hypernatremia | 2 | 0 | 0 | 0 |
| Hyperkalemia | 4 | 1 | 0 | 0 |
| AST/ALT increased | 8 | 0 | 2 | 0 |
| Cr increased | 6 | 0 | 2 | 0 |
| Hot flashes | 9 | 0 | 0 | 0 |
| Constipation | 3 | 0 | 0 | 0 |
| Malaise | 1 | 0 | 0 | 0 |
| Penile pain | 1 | 0 | 0 | 0 |
| Device related infection | 0 | 0 | 1 | 0 |
| Upper respiratory infection | 0 | 1 | 0 | 0 |
| Arthralgia | 1 | 0 | 0 | 0 |
| Urinary frequency | 2 | 0 | 0 | 0 |
| Depression | 1 | 0 | 0 | 0 |
| Pruritus | 1 | 0 | 0 | 0 |
| Gynecomastia | 1 | 0 | 0 | 0 |
| Laryngopharyngeal dysesthesia | 1 | 0 | 0 | 0 |
| Irregular menstruation | 1 | 0 | 0 | 0 |
| Dizziness | 2 | 0 | 0 | 0 |
| Dysgeusia | 1 | 0 | 0 | 0 |
| Erythema multiforme | 1 | 0 | 0 | 0 |
AST/ALT, alanine transaminase/aspartate aminotransferase ratio; Cr, creatinine.