Figure 1.

BLM and FANCI are significantly associated with response to cisplatin chemotherapy. Scatter-plots of LOO analysis in cisplatin-1 and cisplatin-2 cohorts identifies BLM and FANCI as the only two genes that show significant association with response in both clinical trials, based on both gene expression data (A) and copy number aberration data (B). Red dashed lines indicate significance thresholds based on permutation testing. Color intensity indicates overlapping genes. Association between array expression of BLM, FANCI, and the ratio of BLM+FANCI expression to BRCA1, and response to cisplatin chemotherapy in cisplatin-1 (C, E, G), cisplatin-2 (D, F, H) and OV01 carboplatin-treated (I, J, K) and OV01 paclitaxel-treated (L, M, N) cohorts. Red dots indicate the BRCA1 mutant cases.