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. 2018 Feb 20;35(5):1063–1077. doi: 10.1093/molbev/msy022

Fig. 1.

Fig. 1.

Sequence features of miR-941 sponge gene TP73-AS1. (a) Numbers of miR-941 binding sites within noncoding putative target transcripts. (b) Location of nine miR-941 binding sites within the TP73-AS1 gene shown by vertical bars. The five TP73-AS1 isoforms are based on RefSeq annotations: exons—boxes, introns—lines. (c) The schematic representation of base-pairing interaction between miR-941 and TP73-AS1. The interaction features the 9-nt-long extended seed region match, as well as the presence of adenosine at position 9 of the target site (purple). The canonical seed region is shown in red. (d) The enrichment of the miR-941 subseed motif in the vicinity of miR-941 binding sites. The x-axis shows the start position of each 3-mer motif relative to the miR-941 mature sequence. The background frequency of each 3-mer motif was estimated by 1,000 permutations of target noncoding transcript sequences retaining the same dinucleotide composition.