Table 2.

Summary of drinking, craving and alcohol-related outcomes analysis

Phase		Laboratory			Naturalistic			Statistical model
Drinking outcomes		Number of SDU			DD
Medication	Dose (mg)	n	P	f	n	P	f
Aripiprazole	15	25	n.s.	–	30	n.s.	–	Alone with topiramate as covariate
	7.5	29	n.s.	–	30	n.s.	–
	Collapsed	54	n.s.	–	60	n.s.	–
Topiramate	200	27	n.s.	–	30	0.048	0.36	Alone with aripiprazole as covariate
	100	26	n.s.	–	30	n.s.	–
	Collapsed	53	n.s.	–	60	0.03	0.26
Aripiprazole	Collapsed	54	n.s.	–	60	n.s.	–	Interaction with topiramate
Topiramate	Collapsed	53	n.s.	–	60	0.015	0.26	Interaction with aripiprazole
Craving outcomes		AUQ			AUQ
Medication	Dose (mg)	n	p	f	n	p	f
Aripiprazole	15	25	n.s.	–	30	n.s.	–	Alone with topiramate as covariate and interaction with time
	7.5	29	n.s.	–	30	n.s.	–
	Collapsed	54	n.s.	–	60	n.s.	–
Topiramate	200	27	0.04	0.36	30	0.029	0.27	Alone with aripiprazole as covariate
	200	27	n.s.	–	30	0.013	0.31	Alone with aripiprazole as covariate and interaction with time
	100	26	n.s.	–	30	n.s.	–	Alone with aripiprazole as covariate and interaction with time
	Collapsed	53	n.s.	–	60	n.s.	–
Aripiprazole	Collapsed	54	n.s.	–	60	n.s.	–	Interaction with topiramate and time
Topiramate	Collapsed	53	n.s.	–	60	n.s.	–	Interaction with aripiprazole and time
Alcohol-related outcomes		BAES Stimulation/sedation
Medication	Dose (mg)	n	p	f	n	p	f
Aripiprazole	15	25	n.s./n.s.	–	–	–	–	Alone with topiramate as covariate and interaction with time
	7.5	29	n.s./n.s.	–	–	–	–
	Collapsed	54	n.s./n.s.	–	–	–	–
Topiramate	200	27	0.041/n.s.	0.25	–	–	–	Alone with aripiprazole as covariate and interaction with time
	100	26	n.s./n.s.	–	–	–	–
	Collapsed	53	n.s./n.s.	–	–	–	–
Aripiprazole	Collapsed	54	n.s./n.s.	–	–	–	–	Interaction with topiramate and time

Source: AUQ, Alcohol Urge Questionnaire; BAES, Biphasic Alcohol Effect Scale; DD, Drinking Days; SDU, Standard Drink Unit; n.s.: no significant. Bold values indicate statistical significance.