Table 5. Gene annotation and sequence location from STRING and ERC webserver searching from D. melanogaster genome. Genes with high ERC value (> 0.400) and p-value < 0.05 are colored gray.

Gene	Annotation	Description
Atac3	CG32343	Contributes to histone acetyltransferase activity. Involved chromatin remodeling.
Cap	CG18408	Interacts selectively and non-covalently with vinculin, a protein found in muscle, fibroblasts, and epithelial cells that binds actin and appears to mediate attachment of actin filaments to integral proteins of the plasma membrane.
CG10262	CG10262	Proliferating Cell Nuclear Antigen (PCNA) domain. These polymerase processivity factors play a role in DNA replication and repair.
CG13035	CG44836	Uncharacterized protein involved in sensorial perception of pain.
CG14618	CG14618	Belongs to the class IV-like SAM-binding methyltransferase superfamily. tRNA (guanine(9)-N(1))-methyltransferase TRM10. Enzyme catalyzes the conversion of a guanosine residue to N1-methylguanine in position 37, next to the anticodon, in tRNA.
CG14906	CG14906	N-6 adenine-specific DNA methylases. Specifically methylate the amino group at the C-6 position of adenines in DNA.
CG16863	CG16863	The protein has zinc finger, BED-type, which is thought to be involved in chromatin insulation at BEAF (boundary element-associated factor) and DREF, a transcriptional regulator.
CG17124	CG17124	PKC-activated protein phosphatase-1 inhibitor. Stops, prevents or reduces the activity of a protein phosphatase, an enzyme that hydrolyzes phosphate groups from phosphorylated proteins.
CG6712	CG6712	Probably RNA binding inferred from sequence or structural similarity with Saccharomyces RPF1, involved in ribosome biogenesis. Belongs to Brix superfamily.
CG7470	CG7470	Predicted gamma-glutamyl phosphate reductase with delta1-pyrroline-5-carboxylate synthetase activity, glutamate 5-kinase activity. An inner mitochondrial membrane enzyme, is essential to the de novo synthesis of the amino acids proline and arginine. Involved in epithelium development and germarium-derived egg chamber formation.
CTCF	CG8591	CTCF is a ubiquitous transcription factor that binds to insulators and domain boundaries. It mediates insulator function and blocks enhancers by binding to Cp190. It contributes to long-range chromatin interaction, organizes chromatin domain boundaries and coordinates nuclear architecture.
Dnmt2	CG10692	Methyltransferase 2 is a (cytosine-5) DNA/tRNA methyltransferase. It is involved in regulation of gene expression by cytosine-5 methylation. The major protein role is the modifications that protects tRNAs against endonucleolytic cleavage and contributes to stress resistance, protein translation and small RNA-mediated gene regulation.
Eggless	CG12196	Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Involved in negative regulation of gene expression.
Eno	CG17654	Responsible for the catalysis of the conversion of 2-phosphoglycerate (2-PG) to phosphoenolpyruvate (PEP), the ninth and penultimate step of glycolysis
Haywire	CG8019	Helicase Ercc3, core RNA polymerase binding transcription factor activity. Involved in regulation of alternative mRNA splicing, via spliceosome, cell proliferation and growth.
Homer	CG11324	Involved in the positive regulation of circadian sleep/wake cycle, sleep; response to ethanol, behavioral response to ethanol, regulation of locomotion and adult behavior. Activity in stress response.
hop	CG1594	Signal transduction-non receptor tyrosine kinase. Members of the Janus kinase (JAK) family of cytoplasmic protein tyrosine kinases physically associate with ligand-bound receptors. The JAK-STAT pathway regulates the expression of pair rule gene even-skipped (a transcriptional repressor of a number of genes) early in embryogenesis.
Hsp22	CG4460	A key player in cell-protection mechanisms against oxidative injuries and aging in Drosophila. Activated in late third-instar larvae of Drosophila melanogaster in the absence of heat stress
MBD-like	CG8208	Methyl Binding Protein 2/3, a co-repressor and an integral component of the nucleosome remodelling and deacetylase (NuRD) complex. Negative regulation of transcription, involved in organism development
mei-S332	CG5303	Acts to maintain sister-chromatid cohesion before anaphase II of meiosis in both males and females.
mms4	CG12936	Methyl methanesulfonate sensitivity 4 is the non-catalytic subunit of the mus81-mms4 structure-selective endonuclease that functions in DNA repair.
mus209	CG9193	Belongs to the PCNA family. Involved in eggshell chorion gene amplification, DNA replication, mismatch repair, neurogenesis and antimicrobial humoral response.
Nsun2	CG6133	tRNA (cytosine-5-)-methyltransferase activity.
Orc2	CG3041	Origin recognition complex subunit 2. It is involved in eggshell chorion gene amplification, chromatin silencing, cell proliferation, DNA replication initiation, chromosome condensation and neurogenesis.
Pnt	CG17077	It is a sequence-specific DNA binding transcription factor activity, repressing transcription factor binding, involved in positive regulation of transcription. It is involved in organism developmental process, open tracheal system development, post-embryonic organ morphogenesis, regulation of developmental process, sensory organ development, cardiovascular system development, regulation of RNA metabolic process, positive regulation of cell proliferation, anterior/posterior axis specification, multi-organism reproductive process, muscle cell differentiation, compound eye photoreceptor development, regulation of neurogenesis.
Rel	CG11992	Relish is a transcription factor and the downstream component of the Immune Deficiency pathway, which regulates the antibacterial response and other less characterized cellular processes.
RhoGEF4	CG8606	Rho family small GTPases act as molecular switches that regulate neuronal morphogenesis, including axon growth and guidance, dendritic spine formation, and synapse formation. These proteins are positively regulated by guanine nucleotide exchange factors (GEFs) of the Dbl family. Findings suggest that DRhoGEF4 may participate in cytoskeleton-related cellular events by specifically activating RhoA in neuronal morphogenesis.
Rpd3	CG7471	Histone deacetylase 1. Catalyzes the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation may constitute a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. For instance, deacetylation of histone H3 may be a prerequisite for the subsequent recruitment of the histone methyltransferase Su(var)3-9 to histones. Involved in position-effect variegation (PEV).
Rpp20	CG33931	A subunit of the RNase P and RNase MRP holoenzymes, has interaction with the Drosophila SMN protein. Immunofluorescence results indicate that Rpp20 is diffusely distributed throughout the cytoplasm with higher concentration observed in the nucleus. However, in response to stress, SMN forms aggregates and redistributes Rpp20 into punctuated cytoplasmic SMN granules.
Sna	CG3956	Snail is a transcription factor that contributes to embryonic mesoderm development, epithelial to mesenchymal transition and asymmetric cell division.
Su(var)2-5	CG8409	Suppressor of variegation 205 is a heterochromatin protein associated with the pericentric heterochromatin and telomeres in Drosophila. It is involved in the positive autoregulatory expression and can bind directly to nucleosomes.
Su(var)2-10	CG8068	It is responsible for establishing and maintaining chromosome organization in interphase nuclei, promoting chromosome structure and function.
Su(var)3-3	CG17149	Probable histone demethylase that specifically demethylates ‘Lys-4’ of histone H3, a specific tag for epigenetic transcriptional activation, thereby acting as a corepressor. Required for heterochromatic gene silencing
Su(var)3-9	CG43664	Histone methyltransferase that specifically trimethylates ‘Lys-9’ of histone H3 using monomethylated H3 ‘Lys-9’ as substrate. H3 ‘Lys-9’ trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting Su(var)205/HP1 to methylated histones. Mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric regions. Involved in heterochromatic gene silencing including the modification of position-effect-variegation.
Tet	CG9973	Ten-Eleven Translocation (TET) family protein. Involved in positive regulation of DNA demethylation, inducing positive regulation of transcription from RNA polymerase II promoter.
Thor	CG8846	Eukaryotic translation initiation factor 4E binding protein, controlled by tor. It contributes to translation regulation, response to environmental stress and cell growth regulation.