FIG 6.

Metabolic pathway analyses for infected and control mice. (A and B) MetaboAnalyst was used to identify the metabolic pathways that are important for the host response to E. falciformis infection on day 7 (A) or 14 (B). A darker circle color indicates more-significant changes in the metabolites in the corresponding pathway, while the size of each circle corresponds to the pathway impact score: larger circles reflect higher centrality of the metabolites involved. (C and D) Up- and downregulated metabolites of all major pathways enriched in E. falciformis-infected mice on day 7 (C) or 14 (D).