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Functional analysis of the COX-2 inhibitor. PBMCs from uninfected cattle (n = 9 [a and b] or 8 [c]) were cultured with meloxicam in the presence of anti-CD3 and anti-CD28 MAbs. CD8+ cell proliferation was assayed by flow cytometry (a). IFN-γ (b) and TNF-α (c) production was determined by ELISA in duplicate. Statistical significance was determined by the Wilcoxon signed-rank test.
