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RPR-induced bone resorption activity for osteoclasts. a Human PBMCs or murine RAW264.7 macrophages were placed on a synthetic bone cell culture and then treated with RANKL and M-CSF or RPR. After 7 or 14 days of culture, cells were separated. Microscopy was used to determine the number of pits in each well, which were photographed. b Data are the mean ± SD from three independent tests; *p < 0.01, **p < 0.001, compared with the medium as the singular control
