TABLE 4.
Parameter estimates for the final PD model
| Parameter (unit) | Definition | Estimate | SIR median (95% CI) |
|---|---|---|---|
| N0 (10CFU/ml)a | Initial bacterial count | 6.80 | 6.79 (6.45–7.10) |
| Kg (h−1) | Bacterial growth rate constant | 1.04 | 1.03 (0.89–1.13) |
| Nmax (10CFU/ml)a | Maximum bacterial count | 9.41 | 9.61 (8.96–10.29) |
| Emax (h−1) | Maximum killing rate constant | 9.38 | 9.38 (7.36–11.91) |
| EC50 (mg/liter) | Plasma drug concn to achieve 50% maximum killing rate | 3.49 | 3.46 (2.52–4.79) |
| α (liter/mg · h) | Rate of bacterial adaptation constant | 0.0143 | 0.0143 (0.013–0.016) |
| β | Maximum bacterial adaptation | 29.2 | 30.4 (23.8–38.3) |
| ISV N0 (SD) | Interstudy variability in N0 | 0.91 | 0.914 (0.769–01.018) |
| ISV Kg (% CV) | Interstudy variability in Kg | 23 | 23.0 (217–24.8) |
| ISV Emax (% CV) | Interstudy variability in Emax | 33.9 | 33.9 (31.8–36.2) |
| IAV N0 (SD) | Inter-arm variability in N0 | 0.14 | 0.14 (0.12–0.16) |
| RUVstatic | Log10 residual error for static studies | 0.86 | 0.85 (0.61–1.02) |
| RUVdynamic | Log10 residual error for dynamic studies | 0.57 | 0.58 (0.47–0.67) |
a
10CFU/ml, 10^estimated parameter (CFU/ml).