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Pharmacokinetic properties of JPC-3210 in healthy and Plasmodium berghei (ANKA strain)-infected mice following a single oral dose of 80 mg/kg of JPC-3210
| Compartment and animal status | Cmax (ng/ml) | Tmax (h) | t1/2 (h) | AUC (μg · h/liter) | V/F (liters/kg) | CL/F (ml/h/kg) |
|---|---|---|---|---|---|---|
| Plasma | ||||||
| Healthy | 4,015 | 1 | 137 | 199,951 | 79 | 400 |
| Infected | 2,652 | 1 | 125 | 219,018 | 66 | 365 |
| Blood | ||||||
| Healthy | 2,929 | 1 | 152 | 224,244 | 78 | 357 |
| Infected | 3,407 | 0.5 | 106 | 268,886 | 46 | 298 |
