FIG 4.

Drug-induced changes on in vitro overall signature of high cytokine producers. Signatures of high frequency of cytokine-producing cells from innate (CD14) and adaptive (CD4, CD8, CD19) immune compartments by noninfected subjects (NI, n = 18) and Chagas disease patients (CD, n = 20) after treatment with BZ (blue bars), K777 (red bars), PYR (green bars), and FUR (pink bars) lead compounds. The ascendant frequency of cytokine-producing cells from innate and adaptive immune compartments in each group is represented by bars. Dotted lines represent the 50th percentile that was used as a cutoff to identify relevant differences. The results are presented as exposure index (EI = value for treated cultures/value for control cultures).