Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Pharmacokinetic parameters of lascufloxacin in plasma, ELF, and AMa
| Sample | Tmax (h) | Cmax (μg/ml) | AUC0–24 (μg · h/ml) | Site-to-plasma Cmax ratio | Site-to-free plasma Cmax ratio | Site-to-plasma AUC0–24 ratio | Site-to-free plasma AUC0–24 ratio |
|---|---|---|---|---|---|---|---|
| Plasma | 1 | 0.576 | 7.67 | ||||
| ELF | 1 | 12.3 | 123 | 21.4 | 82.1 | 16.0 | 61.7 |
| AM | 6 | 21.8 | 325 | 37.8 | 146 | 42.4 | 163 |
Pharmacokinetic parameters were calculated from the mean concentration-time profile of lascufloxacin. ELF, epithelial lining fluid; AM, alveolar macrophages.
