TABLE 1.
Comparison of drug resistance and susceptibility in isolates from different hosts
| Antimicrobial agent | No. (%) of isolatesa |
P valueb (pMAH vs HIV) | |||
|---|---|---|---|---|---|
| pMAH (n = 46) |
HIV (n = 30) |
||||
| R | S | R | S | ||
| Clarithromycin | 1 (2.2) | 45 (97.8) | 3 (10.0) | 27 (90.0) | 0.294 |
| Rifampin | 1 (2.2) | 45 (97.8) | 0 (0) | 30 (100) | 1 |
| Ethambutol | 39 (84.8) | 7 (15.2) | 13 (43.3) | 17 (56.7) | ≤0.001 |
| Streptomycin | 14 (30.4) | 32 (69.6) | 5 (16.7) | 25 (83.3) | 0.278 |
| Kanamycin | 15 (32.6) | 31 (67.4) | 4 (13.3) | 26 (86.7) | 0.065 |
| Amikacin | 7 (15.2) | 39 (84.8) | 3 (10.0) | 27 (90.0) | 0.731 |
| Ethionamide | 30 (65.2) | 16 (34.8) | 10 (33.3) | 20 (66.7) | 0.009 |
| Levofloxacin | 0 (0) | 46 (100) | 1 (3.3) | 29 (96.7) | 0.395 |
a
The breakpoints of the antimicrobial agents were determined according to the criteria described in the BrothMIC NTM system manual and Materials and Methods. pMAH, isolates from the sputa of patients with pulmonary M. avium subsp. hominissuis disease; HIV, isolates from the blood of HIV-positive patients with disseminated M. avium subsp. hominissuis disease; R, resistant; S, susceptible.
b
P values were calculated using Fisher's exact test.