FIG 5.
Comparison of the population PK parameter values estimated in our study and the studies of Van Wart et al. (18), Rubino et al. (19), and Ramirez et al. (16). The boxplots show the mean values and standard deviations of the parameter. For the study by Rubino et al. (19), the standard deviations of the mean clearance estimates were obtained from bootstrap results. CL, clearance; Vss, volume of distribution at steady state; Q, intercompartmental clearance; V1, volume of distribution of the central compartment; V2, volume of distribution of the peripheral compartment.