TABLE 2.
Final model parameter estimates
| Parametera | Estimate | RSE (%) | Shrinkage (%) | Bootstrap analysis |
|
|---|---|---|---|---|---|
| Median | 90% CIb | ||||
| Mean population parameters (θ) | |||||
| θCL (liters/h) | 22.1 | 3.16 | 22.1 | 20.9–23.2 | |
| θV1 (liters) | 162 | 5.3 | 163 | 150–176 | |
| θQ (liters/h) | 69.4 | 32.6 | 67.3 | 41.9–98.4 | |
| θV2 (liters) | 87.9 | 8.67 | 87.6 | 76.1–101 | |
| Interindividual variability (ω2) | |||||
| ω2CL (% CV) | 17.3 | 19 | 7.3 | 17.1 | 14.2–19.7 |
| ω2V1 (% CV) | 19.2 | 29.2 | 6.7 | 19.1 | 14.3–23.7 |
| ω2Q (% CV) | 0 FIXc | ||||
| ω2V2 (% CV) | 38.7 | 40.8 | 22.4 | 37.4 | 20.4–48.5 |
| Interoccasion variability (π2) | |||||
| π2CL (% CV) | 14.4 | 35 | 14.2 | 9.4–18.1 | |
| Occasion 1 | 27.4 | ||||
| Occasion 2 | 38.5 | ||||
| Occasion 3 | 52.4 | ||||
| Occasion 4 | 42.6 | ||||
| Occasion 5 | 35.4 | ||||
| Occasion 6 | 48.4 | ||||
| Occasion 7 | 94.9 | ||||
| Occasion 8 | 99.8 | ||||
| π2V2 (% CV) | 20.8 | 66.4 | 21.7 | 0.200–30.9 | |
| Occasion 1 | 40.2 | ||||
| Occasion 2 | 50.2 | ||||
| Occasion 3 | 58.5 | ||||
| Occasion 4 | 56.4 | ||||
| Occasion 5 | 52.9 | ||||
| Occasion 6 | 57.2 | ||||
| Occasion 7 | 90.6 | ||||
| Occasion 8 | 99.6 | ||||
| Residual error model | |||||
| σadd (μg/ml) | 0.0210 | 0.41 | 0.0224 | 0.000209–0.0357 | |
| σ2prop (% CV) | 13.0 | 17.7 | 12.7 | 8.89–16.1 | |
a
σadd, additive residual random error; σ2prop, variance of proportional residual random error.
b
90% CI (confidence intervals) of the parameter estimates were derived from a nonparametric bootstrap analysis (n = 1,000; unsuccessful, 1).
c
0 FIX indicates that parameter value was fixed at 0 and not estimated.