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Hollow-fiber infection model of cryptococcal meningitis. (A) Pharmacokinetics of flubendazole with the three arms with intended peak concentrations of 1.25, 2.5, and 10 mg/liter; (B) pharmacodynamics in response to flubendazole administered at various doses q24h. Therapy was initiated 24 h postinoculation, after which time Cryptococcus had grown from ∼6 log10 CFU/ml to 8 log10 CFU/ml.
